Study: No Toxicity Seen with 5,000 to 50,000 IU Vitamin D per Day

The Journal of Steroid Biochemistry and Molecular Biology

Volume 189, May 2019, Pages 228-239

Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience


• Daily dosing with vitamin D ranged from 5000 IU/day to 50,000 IU/day.
• No cases of hypercalcemia observed using these doses of vitamin D for up to 7 years.
• The highest 25OHD blood level attained on 10,000 IU/day was 202 ng/ml.
• Mean 25OHD levels on 10,000 IU/day were 96 ng/ml and 116 ng/ml in 2 data sets.
A case of asthma and psoriasis were controlled with 25,000 IU/d and 50,000 IU/d.


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