
https://www.medrxiv.org/content/10.1101/2021.09.22.21263977v1.full-text

Posted September 25, 2021.
COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis
Lorenz Borsche, Bernd Glauner, PJulian von Mendel
doi: https://doi.org/10.1101/2021.09.22.21263977
Now published in Nutrients doi: 10.3390/nu13103596
Discussion
This study investigated the correlation between vitamin D levels as a marker of a patient’s immune defense and resilience against COVID-19 and presumably other respiratory infections. It compared and merged data from two completely different datasets. The strength of the chosen approach lies in its diversity, as data from opposite and independent parts of the data universe yielded similar results. This result strengthens the hypothesis that a fatal outcome from COVID-19 infection, apart from other risk factors, is strongly dependent on the vitamin D status of the patient. The mathematical regressions suggested that the lower threshold for healthy vitamin D levels should lie at approximately 125 nmol/L or 50 ng/ml 25(OH)D3, which would save most lives, reducing the impact even for patients with various comorbidities.
This is – to our knowledge – the first study that aimed to determine an optimum D3 level to minimize COVID-19 mortality, as other studies typically limit themselves to identifying odds ratios for 2–3 patient cohorts split at 30 ng/ml or lower.
Another study confirmed that the number of infections clearly correlated with the respective D3 levels, with a cohort size close to 200,000 [115]. A minimum number of infections was observed at 55 ng/ml. …
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